The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.

Promotor: A. Kros

The following report discusses a survey on the topic of the Sustainable Development Goals that was distributed among researchers at Leiden University in the month of November 2021.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Laboratory, observation and modeling work on the dissociation of polycyclic aromatic hydrocarbons in interstellar environments and the formation of new molecular species through the fragmentation process.

A brief review essay on some of the work that has been recently published in the emergent field of digital ethnography.

This course uses the lives, ideals and achievements of Theodore, Franklin, and Eleanor Roosevelt to create the idea of a Rooseveltian century. It is an invitation to think critically and historically, and it wants to give you a glimpse of what it means to be a historian at work.

This course provides an insider perspective into the work of international criminal courts and tribunals. You will learn about the investigation and prosecution of international crimes in The Hague.

Aangezien jeuk en pijn zeer belastend kunnen zijn, vooral wanneer mensen chronisch aan (een van) deze symptomen lijden, is het belangrijk te weten door welke factoren deze gewaarwordingen worden beïnvloed. Het wordt steeds duidelijker dat psychologische factoren een belangrijke rol spelen bij het ervaren…

Het tijdschrift 'East European Politics' publiceert artikelen over politiek, bestuur en internationale betrekkingen van de post-communistische landen.

Public Administration is a major refereed journal publishing articles on public administration, public policy and public management.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

Res Publica een Nederlandstalige wetenschappelijk tijdschrift voor politieke wetenschap, bestuurskunde, Europese en internationale politiek, politieke sociologie en communicatiewetenschap.

Regional & Federal biedt een wetenschappelijk platform aan wetenschappers die zich bezighouden met internationaal onderzoek op deze gebieden.

Acta Politica is het officiële wetenschappelijke tijdschrift van de Nederlandse Kring voor de Wetenschap der Politiek.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Naast het feit dat angstproblemen veelvoorkomend zijn en het daarom belangrijk is om hier effectieve preventieve programma’s en behandelingen voor te ontwikkelen, is dat in deze tijd extra relevant.

What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?

M. Danhof, Co-promotores: J. Freijer, A. Yassen

Promotie

Promotie

The key purpose of this project is to study tautological relations on the level of closed differential forms or even integral cochains (i.e. we don't take classes in cohomology).

The coursework within the Science Communication and Society (SCS) specialisation prepares students for internships and a career in communication about science and health.

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Creating a framework to assess the sustainability of fish farms which will set sustainability standards and give consumers information about the the sustainability and safety of their seafood.

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

PhDArts co-director Dr. Janneke Wesseling’s e-book ‘De volmaakte beschouwer, De ervaring van het kunstwerk en receptie-esthetica’ was recently published. The key question of the book is: how does the work of art work?

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Possible improvements for the assessment of abiotic depletion in LCA.

Met dit project wordt van een evidence-based onderwijsmethodiek (toolkit) ontwikkeld voor docenten van alle vakgebieden in het hoger onderwijs voor het effectief omgaan met controversiële onderwerpen in de les.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

The mission of our group is understanding how science communication works to improve the interaction between science and society. We believe better science communication can improve our society and engage many different groups with science, also improving science.

Geesteswetenschappen, Centre for Linguistics

Geesteswetenschappen, Centre for Linguistics

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

Hoe kunnen nierpatiënten geholpen worden een gezonde leefstijl aan te nemen? Gezondheidspsycholoog Sandra van Dijk gaat dit onderzoeken met een persoonsgebonden subsidie van de Nierstichting.

Bacteriën leven tijdelijk zonder hun celwand als er voor hen gevaarlijke virussen in de buurt zijn. Opmerkelijk, want de celwand vormt een stevige barrière tegen dreigingen van buitenaf. Toch is de vondst goed te verklaren én kan het een gevolg hebben voor het bestrijden van ziekteverwekkende bacteriën,…

Promotores: Prof.dr. J. Schaye & Prof.dr. C. Steidel (California Institute of Technology)

The main topic of this PhD thesis is the Arakelov ray class group of a number field, an algebraic object that contains both the ideal class group structure and the unit group structure.

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.