In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.

Identification of the products or product groups that have the greatest environmental impact from a life-cycle perspective using environmentally extended input-output analysis.

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

Promotor: Prof.dr. A. Achucarro

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

Galaxy intrinsic alignments induce a major astrophysical contamination to weak gravitational lensing measurements and need to be modelled and mitigated when extracting cosmological information from such measurements.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Hoe en in welke mate kunnen groepen clinici en biomedici kennis uit klinische vakken en kennis uit de basisvakken expliciet maken en aan elkaar relateren?

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

Promotor: E.F. Smets, Co-promotor: J. Geml

We explored the Universe using weak gravitational lensing, a phenomenon that occurs when light from distant galaxies is bent by the gravitational fields of closer cosmic objects, much like how a lens distorts light.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Promotor: Prof.dr. B. van de Water

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Op 7 december 2021 verdedigde Georgina Kuipers het proefschrift 'Beschadigd vertrouwen'. Het promotieonderzoek is begeleid door prof.mr. W. den Ouden en prof.dr. M.A. van der Steen (EUR).

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Dit artikel geschreven door Marieke Liem & Alexander Kamprad onderzoekt de relatie tussen terrorisme en interpersoonlijk geweld. Ze voerden cross-nationale analyses uit over de effecten van mortaliteitscijfers voor het terrorisme op moordcijfers. Uit de resultaten bleek dat terrorisme sterk en positief…

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

This PhD thesis concerns the topic of arithmetic geometry. We address three different questions and each of the questions in some way is about counting how big some set is or can be.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

Op 1 april 2020 verdedigde Marc Broekema zijn proefschrift 'Cognitive Bias in the Judgment of Business Valuations and Valuators'. Het promotieonderzoek is begeleid door promotor prof. dr. J.I. van der Rest.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Promotor: J.N. Kok, Co-promotor: C.M. Soares, A.J. Knobbe

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

The experiences of ethnic ‘Other’ females have – until recently – been widely overlooked in the study of sport. There continues to be a need to produce critical scholarship about ethnic 'Other' girls and women in sport and physical culture, in order to represent their complex, multifarious and dynamic…

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.