Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC), Leids Instituut voor Onderzoek in de Natuurkunde (LION)

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

The experiences of ethnic ‘Other’ females have – until recently – been widely overlooked in the study of sport. There continues to be a need to produce critical scholarship about ethnic 'Other' girls and women in sport and physical culture, in order to represent their complex, multifarious and dynamic…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Debat

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.

Studievoorlichting, Online Experience

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

Promotor: G.J.B. van Ommen

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

This thesis aims to address offshore wind energy (OWE)-related environmental impacts.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

This report investigates the different approaches in the authorization process of GMOs for commercial use in the European Union and the United States of America. Three main aspects are considered and analyzed as potential causes of differences in the authorization process of GMOs for commercial use.…

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

This PhD research sets out to unravel and explain the socio-structural and cultural impacts of oil-industrialization on the local Bakhtiari community in general and the industrial laborers it provided in specific.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

Promotores: P. Stevenhagen, L. van Geemen (Università degli studi di Milano), Co-Supervisor: Ronald M. van Luijk

Promotores: S.J. Edixhoven, F. Andreatta

LIACS is a partner in the EU Erasmus+ Curriculum Development for the Asian education system. The knowledge available in the field of Data Science and Artificial Intelligence education will be shared and adapted for the Asian market.

Geesteswetenschappen, Centre for the Arts in Society

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

Word een expert op het gebied van migratie- en diversiteitsrecht met een multidisciplinaire focus. Naarmate samenlevingen steeds diverser worden, bereidt dit programma je voor op het aanpakken van de juridische uitdagingen die wereldwijde migratie met zich meebrengt. Je leert het recht te begrijpen…

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

Promotor: A. Achúcarro, Co-Promotor: G.A. Palma

De eerstejaarsstudenten van de Bachelor Security Studies hebben hun laatste blok afgesloten met het vak 'Integrated Project 1'.

What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…

Samuel Jong behaalt de masterscriptieprijs 2016 van het Instituut Politieke Wetenschap. Met ‘Bridging the Gap: Do Ideological Differences Determine Whether Center-Right Parties Cooperate with the Radical Right?’, rondde Jong zijn master Political Science af. Zijn bevindingen, zijn naar het oordeel van…

This dissertation takes an important step in understanding the phenomenon of non-take-up of social support and what it means for contemporary social policies.

Op 7 december 2021 verdedigde Georgina Kuipers het proefschrift 'Beschadigd vertrouwen'. Het promotieonderzoek is begeleid door prof.mr. W. den Ouden en prof.dr. M.A. van der Steen (EUR).

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Promotor: S.M. Verduyn Lunel

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

How can mega sand nourishments, such as the Sand Motor, be designed and managed for optimal ecosystem services provision ?

There is accumulating evidence for an increase in severe global drought events. In particular, Europe experienced several severe droughts in 2003, 2015, and 2018 (unprecedented in the past 2,110 years). Such droughts have caused serious and far-reaching impacts on terrestrial ecosystems.

Promotor: Prof.dr. M.K. Richardson

Songbirds as vocal learners learn their songs and song preference from social tutors⁠. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song⁠.