Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary.

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Including modelling as part of software development appears to have various benefits.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

An interdisciplinary collection of the best international scholarship on Muslim youth.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

Things that Matter: Material and Culture in/for the Digital Age. Bern, 23-27 June 2025.

Hoe kunnen we sociale cohesie bevorderen in een samenleving die cultureel en religieus divers is?

De onderzoeksgroep Organizational & Entrepreneurial Behavior onderzoekt het gedrag van individuen en groepen die in organisaties werken, organisaties starten, of organisaties leiden, met als doel om organisatorische praktijken te informeren. Door zich te concentreren op het gedrag van (groepen) werknemers,…

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC), Leids Instituut voor Onderzoek in de Natuurkunde (LION)

Mirjam Bekker is op 15 november 2012 begonnen met haar promotieonderzoek binnen het 'Crime and Gender' project van Manon van der Heijden.

Op 4 november verdedigde duaal promovenda Hester Diderich-Lolkes de Beer haar proefschrift 'Detection of child maltreatment based on parental characteristics at the hospital Emergency Department’.

Van onderwijs tot een verrijkende ervaring

CREEA is a FP7 project on compiling and refining environmental and economic accounts. The project runs from April 2011 to March 2014.

Promotor: P.M. Brakefield

In this thesis, several aspects of software debugging from automated crash reproduction to bug report analysis and use of contracts have been studied.

The Leiden Institute of Advance Computer Science (LIACS) in collaboration with the Institute of Security and Global Affairs (ISGA) have developed the minor Cyber Security Governance Essentials to provide students with a mixture of technical and governance knowledge to set them on a path towards understanding…

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

The project Multimedia Research and Documentation of African Oral Genres: Connecting Diasporas and Local Audiences (Director: D.Merolla) focuses on multimedia as technology that allows scholars to share documentation and scientific knowledge with the cultural owners of the collected oral genres.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Promotor: M. Franx, Co-Promotor: I.F. Labbé

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

An important part of the SCS specialisation is the internship period. Students will get the opportunity to get to know the field and to apply what they have learned during the courses.

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.