1,567 zoekresultaten voor “paul 1991 1990 disease worden” in de Publieke website
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Predicting Outcomes in Patients with Kidney Disease
Promotie
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Adult weight change and cardiometabolic disease
Promotie
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Conceptualisation of disease resolution in rheumathoid arthritis
Promotie
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Cardiovascular disease burden in thoracic aortopathy
Promotie
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Inflammatory Bowel Disease in Older Patients
Promotie
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Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
Cardiovascular diseases are still a major concern for the global health.
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Wiskundig model helpt ontstaan van wervels en ribben te verklaren
Leidse wiskundig biologen hebben een model ontwikkeld dat helpt verklaren hoe onder meer de ruggengraat en de wervels ontstaan in de embryonale ontwikkeling. Hetzelfde proces, maar dan andersom, speelt een sleutelrol bij de uitzaaiing van kanker. Publicatie in iScience.
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Indo-Europees Etymologisch Woordenboek
Dit project identificeert en beschrijft de belangrijkste Indo-Europese talen en taaltakken en heeft tot dusver geresulteerd in twaalf delen, gepubliceerd als The Leiden Indo-European Etymological Dictionary Series (Brill, Leiden).
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Profielwerkstuk
Antibiotica, bacteriën en resistentie zijn zeer geschikte onderwerpen voor een profielwerkstuk. Hier vind je alvast een aantal handige links.
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Maria YazdanbakhshFaculteit Geneeskunde
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Jordy van der BeekWiskunde en Natuurwetenschappen
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Targeting Inter-Organ Cross-Talk in Cardiometabolic Diseases
Promotie
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Gevaarlijke microben in lager veiligheidslevel lab? Met een nieuwe techniek zou het kunnen
Onderzoekers moeten in een gespecialiseerde omgeving werken zodra ze aan de slag gaan met gevaarlijke bacteriën en virussen. Alleen in laboratoria met een hoog bio-veiligheidsniveau mogen ze deze microben bestuderen. Helaas zijn dure microscopen nodig om de microben goed te bekijken, maar is dat soms…
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Duurzame campus
De Universiteit Leiden werkt aan een groene, circulaire campus, met een forse energiereductie in 2050 als doel, zoals uitgewerkt in de in 2022 verschenen Routekaart energietransitie gebouwen.
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Visual analytics for spatially-resolved omics data at single cell resolution: Methods and Applications
The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…
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Lipid signaling and inflammation: metabolomics for better diagnosis and treatment strategy
Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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B cell modulation in atherosclerosis
Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.
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Development of personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Involvement of host and bacterial factors in Agrobacterium-mediated transformation
Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Nieuwe stoffen remmen ontsteking in het brein
Leidse chemisch biologen, onder leiding van dr. Mario van der Stelt, hebben stoffen ontdekt die ontstekingsprocessen in de hersenen kunnen verminderen. Daarmee is een eerste stap gezet in de ontwikkeling van potentiële geneesmiddelen voor de behandeling van hersenziekten zoals de ziekten van Alzheimer…
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Capillary Electrophoresis-Mass Spectrometry based Metabolomics Approaches for Volume-restricted Applications
Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…
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NWO-beurs drijft zoektocht naar duurzame productie antibiotica
De kans om een nieuw, spannend onderwerp te onderzoeken. Dat is hoe Lennart Schada von Borzyskowski zijn succesvolle beursaanvraag voor de NWO XS-beurs noemt. Deze 50.000 euro zal de onderzoeker van het Instituut Biologie Leiden (IBL) spenderen aan het ontwikkelen van een nieuwe methode om op duurzame…
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In naam van God
Paul Cliteur en Dirk Verhofstadt gaan op zoek naar de bronnen van het theoterrorisme.
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Multifaceted role of the complement system in health and disease
Promotie
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Role of intestinal microbiota in cardio-metabolic disease
Promotie
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Single-cell mechanics for disease biology and pharmacology
Promotie
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Advanced echocardiographic imaging in valvular and systemic diseases
Promotie
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Early diagnosis and management of celiac disease in childhood
Promotie
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Pharmacotherapy and Ventilatory Control in Health and Disease
Promotie
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Oxidative Stress in Chronic Diseases: Causal Inference from Observational Studies
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Oxidants and antioxidants as targets for cardiovascular disease prevention
Promotie
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Viral gene therapy approaches for CRB1 retinal disease
Promotie
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Genetics and Life Course Epidemiology of Cardiometabolic Disease
Promotie
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4D-Flow MRI of Aortic and Valvular Disease
Promotie
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Developmental cell lineage dynamics in Bicuspid Aortic Valve disease
Promotie
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glycocalyx; a diagnostic and therapeutic target in cardiometabolic diseases
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Metabolomics to predict progression in chronic kidney disease
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Literatuur
Voor de teksten van dit gidsje is de volgende literatuur gebruikt:
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Postmaterialism and Socioeconomic Status Impact in the Chilean Voting Behavior
This paper describes the development process of voting behavior in Chile; particularly the relationship between the class voting theory and the theory of cultural post-materialist vote is investigated. This research deals with Chile as a case study, a developing country with a relatively stable democracy…
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Van Willigen, ‘A Dutch return to UN peacekeeping?’
Niels van Willigen (Instituut Politieke Wetenschap, Universiteit Leiden) plaatst de Nederlandse deelname aan VN vredesmissies in een historische context. Hij bekijkt de redenen voor een afname van de Nederlandse inbreng na 1990 en verkent de obstakels en mogelijkheden voor een ‘Nederlandse terugkeer’…
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…