Promotor: J.W. van Holten

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Promotor: R. Cramer

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

One of the most important correlation functions in physics, especially in cosmology, is the energy density, which describes how much energy is present at each point in spacetime due to matter fields. A key contribution to the energy density of the primordial universe comes from gravitational waves (GWs),…

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Promotor: J. Aarts

Promotor: W.T. de Groot

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Supervisor: P.J.J. Hooykaas

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

Writing an operational guide to the ISO standards for LCA and related sub-projects.

How can we, together international experts, define future needs of R+D contributions for innovations in the field of risk-based management of chemicals and products in a global perspective using alternative testing strategies to minimize animal tests?

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

Promotie

Promotie

Promotie

Promotie

Het Rijksmuseum van Oudheden in Leiden heeft een kleine fototentoonstelling over Mark Driessens veldwerkproject in zuidelijk jordanië. In deze kleine tentoonstelling ziet u een selectie van negen foto’s die zijn gemaakt tijdens het onderzoek van archeologen in Udhruh. Deze Jordaanse nederzetting ligt…

Het vertrekpunt van dit onderzoek is de bevinding dat het menselijk brein vatbaar is voor allerlei denkfouten en vooringenomenheden (biases), die onze percepties kleuren en onze redenaties beïnvloeden, zonder dat we dit bewust doorhebben. Integendeel, mensen hebben veelal het gevoel dat zij slechts…

Waarom is water nat en wat is ADHD? In De Hoe?Zo! Show krijgen nieuwsgierige groep 6-leerlingen antwoord op hun vragen. Promovendi laten zo zien hoe leuk de wetenschap kan zijn én leren ondertussen beter communiceren over hun onderzoek.

Op 16 december 2021 verdedigde Lisanne van Houten het proefschrift 'Flexing the Slot Regime'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof. L. Pierallini (Luiss University Of Rome).

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

Promotores: G.A. Persoon, H.H. de Iongh

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Om de juiste klinische beslissingen te nemen of effectieve diagnostische testen en behandelingen te kunnen ontwikkelen, is het belangrijk om de onderliggende mechanismen van een aandoening of een bepaald gedrag te begrijpen.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

This dissertation presents new cryptographic protocols, which can be divided into two families.