Promotores: G. Persoon, R. Schefold

What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted…

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

LIACS is a partner in RISE_SMA, an interdisciplinary, international network combining excellent scholars and practitioners to enable vigorous knowledge sharing and to develop solutions for contemporary challenges for Social Media Analytics (SMA).

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

Promotor: Prof.dr. M.L. van Hecke

Op 7 december 2021 verdedigde Georgina Kuipers het proefschrift 'Beschadigd vertrouwen'. Het promotieonderzoek is begeleid door prof.mr. W. den Ouden en prof.dr. M.A. van der Steen (EUR).

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

How can we bridge the gap between experts and the general public?

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

This thesis involves three topics: benchmarking discrete optimization algorithms, empirical analyses of evolutionary computation, and automatic algorithm configuration.

The cases of building materials, automobility, mushrooms and plastics.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

ELS@Leiden is deel van een nationaal netwerk van rechtenfaculteiten die activiteiten organiseren en middelen samenbrengen om individuele wetenschappers en onderzoeksgroepen te ondersteunen op rechtenfaculteiten in Nederland.

How presence, abundance and enzymatic activities of AM and EM fungi differently affect soil carbon sequestration processes?

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Although nanoparticles are extensively used in various applications like consumer products and have most probably entered the environment, little is known about the effects of these particles on living organisms.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.

Promotor: J. Schaye

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer

During the course of drug discovery translational steps are made.

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

The unit residue group, to which the present thesis is devoted, is defined using the norm-residue symbol, which Hilbert introduced into algebraic number theory in 1897.

Animal diet studies are critical for understanding ecological processes such as trophic interactions, energy flow, and nutrient cycling. By examining what animals consume, ecologists gain insights into species specialization, predator-prey relationships, and ecosystem management.

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

Galaxy intrinsic alignments induce a major astrophysical contamination to weak gravitational lensing measurements and need to be modelled and mitigated when extracting cosmological information from such measurements.

The mycorrhizal symbiosis is among the most widespread species interactions on Earth⁠. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries⁠.

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

In the CarbonCap project, consumption oriented technological options and policy measures are identified as an addition to the present EU and world climate policy.