703 zoekresultaten voor “neuro cognitive functions” in de Publieke website
-
Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
-
Algebraic techniques for low communication secure protocols
Promotor: R. Cramer
-
Selective autophagy in host defense against mycobacterial infection
The effective treatment of tuberculosis (TB) remains a major challenge to global health.
-
Discovery of BUB1 kinase inhibitors for the treatment of cancer
The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.
-
Low energy electron transmission through layered materials and chiral organic films
In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…
-
Development of new chemical tools to study the cannabinoid receptor type 2
The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.
-
Towards automated identification of metabolites using mass spectral trees
Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers
-
RAISE Onderzoek
Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…
-
Spin dynamics in general relativity
Promotor: J.W. van Holten
-
Substrate adaptability of β-lactamase
The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…
-
Semigroups on Spaces of Measures
Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille
-
Molecular engineering of plant development using Agrobacterium-mediated protein translocation
Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa
-
Inducing spin triplet superconductivity in a ferromagnet
Promotor: J. Aarts
-
Opportunity and Problem in Context (OPiC). A framework for environmental management in developing countries
Promotor: W.T. de Groot
-
Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
-
Dyslipidemia, metabolism and autophagy: antigen-independent modulation of T cells in atherosclerosis
Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.
-
Histone-DNA assemblies in archaea. Shaping the genome on the edge of life
All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).
-
On the 16-rank of class groups of quadratic number fields
Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)
-
Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
-
Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
-
A fixed point approach towards stability of delay differential equations with applications to neural networks
Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans
-
Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
-
Computational, biochemical, and NMR-driven structural studies on histone variant H2A.B
Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.
-
Split Jacobians and Lower Bounds on Heights
This thesis deals with properties of Jacobians of genus two curves that cover elliptic curves.
-
Identification and characterization of viral Xrn1-resistant RNAs
Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.
-
The dynamic organization of prokaryotic genomes: DNA bridging and wrapping proteins across the tree of life
Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.
-
Laura SteenbergenFaculteit der Sociale Wetenschappen
-
Kliniek
U kunt bij ons terecht als u vragen of zorgen heeft over de ontwikkeling van uw kind in de leeftijd van 0 tot 21 jaar.
-
Publiekssymposium Twee Talen - één BeTalen
Wat levert een tweede taal spreken allemaal op, waarom leert de één makkelijker een tweede taal dan de ander en is een dialect ook een eerste taal? De Universiteit Leiden organiseert op 20 mei het Engelstalige publiekssymposium Twee Talen - één BeTalen, over tweetaligheid.
-
Hip fractures and daily functioning in old age
Promotie
-
Deciphering myeloid (progenitor) cell function and communication in (tumor) tissues
Promotie
-
Function and structure of the eye muscles in myasthenia gravis
Promotie
-
CM-values of p-adic Theta-functions
Promotie
-
Juridische oordeelsvorming in het aansprakelijkheidsrecht en financieel toezicht
Het vertrekpunt van dit onderzoek is de bevinding dat het menselijk brein vatbaar is voor allerlei denkfouten en vooringenomenheden (biases), die onze percepties kleuren en onze redenaties beïnvloeden, zonder dat we dit bewust doorhebben. Integendeel, mensen hebben veelal het gevoel dat zij slechts…
-
De Hoe?Zo! Show leert kinderen dat wetenschap helemaal niet saai is
Waarom is water nat en wat is ADHD? In De Hoe?Zo! Show krijgen nieuwsgierige groep 6-leerlingen antwoord op hun vragen. Promovendi laten zo zien hoe leuk de wetenschap kan zijn én leren ondertussen beter communiceren over hun onderzoek.
-
Gold nanoparticle-peptide conjugates for biomedical applications
Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.
-
Can traditional forest management protect and conserve ironwood (ulin) stands? An option and approach in East Kalimantan
Promotores: G.A. Persoon, H.H. de Iongh
-
A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
-
Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
-
Designing Ships using Constrained Multi-Objective Efficient Global Optimization
A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.
-
Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
-
Synthesis of Ribitol Phosphate based Wall Teichoic acids
Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.
-
Metabolomic characterization of plant exudates and their correlation with plant defense systems
Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.
-
Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
-
Key innate immune components controlling intracellular infection
Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer
-
The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine
G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.
-
Flexing the Slot Regime
Op 16 december 2021 verdedigde Lisanne van Houten het proefschrift 'Flexing the Slot Regime'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof. L. Pierallini (Luiss University Of Rome).
-
Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
-
Synthesis of phosphodiester-containing bacterial cell wall components: teichoic acids, capsular polysaccharides and phosphatidyl glycerol analogues
Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée
-
Taking control of charge transfer: strategic design for solar cells
Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda