Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

ELS@Leiden is deel van een nationaal netwerk van rechtenfaculteiten die activiteiten organiseren en middelen samenbrengen om individuele wetenschappers en onderzoeksgroepen te ondersteunen op rechtenfaculteiten in Nederland.

How presence, abundance and enzymatic activities of AM and EM fungi differently affect soil carbon sequestration processes?

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

This thesis involves three topics: benchmarking discrete optimization algorithms, empirical analyses of evolutionary computation, and automatic algorithm configuration.

Op 7 december 2021 verdedigde Georgina Kuipers het proefschrift 'Beschadigd vertrouwen'. Het promotieonderzoek is begeleid door prof.mr. W. den Ouden en prof.dr. M.A. van der Steen (EUR).

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

How can we bridge the gap between experts and the general public?

Promotor: Prof.dr. M.L. van Hecke

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

The cases of building materials, automobility, mushrooms and plastics.

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

Promotor: V. Vitelli, Co-promotor: J. Paulose

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Promotor: Prof.dr. M.K. Richardson

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

Promotor: J.N. Kok, Co-promotor: M.S. Lew

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

During the course of drug discovery translational steps are made.

This thesis applies data mining in commercial settings in the telecommunications industry.

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

In the CarbonCap project, consumption oriented technological options and policy measures are identified as an addition to the present EU and world climate policy.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

Galaxy intrinsic alignments induce a major astrophysical contamination to weak gravitational lensing measurements and need to be modelled and mitigated when extracting cosmological information from such measurements.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.