This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Promotor: T.H. Oosterkamp

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.

Promotor: R.D. Gill, F. Taroni

Promotor: G.R. de Snoo

With the dramatic growth of the image data on the web, there is an increasing demand of the algorithms capable of understanding the visual information automatically.

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Promotor: C. W. J. Beenakker, Yu. V. Nazarov, Co-promotor: J. Tworzydlo

The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.

Promotor: V. Vitelli, Co-promotor: J. Paulose

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

Animal diet studies are critical for understanding ecological processes such as trophic interactions, energy flow, and nutrient cycling. By examining what animals consume, ecologists gain insights into species specialization, predator-prey relationships, and ecosystem management.

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

The unit residue group, to which the present thesis is devoted, is defined using the norm-residue symbol, which Hilbert introduced into algebraic number theory in 1897.

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Promotor: G.P. van Wezel

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

Promotor: J.N. Kok, Co-promotor: M.S. Lew

Biodiversity enables ecosystems to thrive through the synergy of functional differences among organisms. While human well-being strongly depends on biodiversity-driven ecosystem services, human actions are also at the root of current unprecedented biodiversity declines.

Promotor: Prof.dr. M.K. Richardson

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.