This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

Promotor: Prof.dr. S.F. Portegies Zwart

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Promotores: J. Jonkers, K.E. de Visser

Promotores: P. Stevenhagen, A. Enge Co-Promotor: T.C. Streng

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Bicarbonate buffer is largely found in nature due to its ability to regulate pH variations around neutral values. As the pH changes, so does the speciation of the buffer.

In this thesis we investigate cosmology and the large scale structure of the Universe using cosmological simulations.

De Cleveringaleerstoel is ingesteld door de Universiteit Leiden ter herinnering aan hoogleraar Rudolph Pabus Cleveringa en zijn moedige optreden in november 1940 tijdens de Duitse bezetting en ter herdenking van de bevrijding in 1945.

De afdeling eLaw van de Universiteit Leiden is toonaangevend in Europa in onderzoek naar het snijvlak tussen recht en digitale technologieën.

De Hans Franken is een eerbetoon aan prof. dr. mr. Hans Franken, één van de oprichters van eLaw in 1985.

Hieronder staan enkele ervaringen van duale promovendi die gepromoveerd zijn met steun van het Dual PhD Centre.

De Universiteit Leiden reikt regelmatig eredoctoraten, onderscheidingen en prijzen uit.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

Promotor: Prof.dr. S. Haring

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Consequences for sediment stability and seston trapping

Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Indicators to measure progress in de-linking economic growth and environmental pressure.

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Control of infectious diseases poses continuous challenges for human health.

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

Promotor: A.P. IJzerman

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

We consider the propagation of electrical signals through nerve fibres.

Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Promotor: A.P. IJzerman

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Promotor: Prof.dr. J. Kuiper

Op 28 oktober 2021 verdedigde Hein van der Bruggen zijn proefschrift en behaalde daarmee de doctorstitel.

Promotores: H.A. Udo De Haes, P.M. Brakefield

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius