Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Possible improvements for the assessment of abiotic depletion in LCA.

1: What is the relative importance of alfa and beta biodiversity in polar ecosystems, and how does intraspecific variation influence this? 2: How can we use remote sensing to determine functional biodiversity (within communities) in polar ecosystems? 3: Temporal and spatial scales of functional biodiversity:…

Hogere temperaturen leiden wereldwijd tot veranderingen in de vegetatie en de bodem van berggebieden. Een internationaal onderzoeksteam met de Leidse ecoloog Ellen Cieraad publiceerde op 25 januari in Nature over de verstoring van het ecosysteem.

De Leiden Institute for Brain and Cognition (LIBC) Publieksdag, met als thema 'geheugensporen', trok ruim 700 bezoekers.

Onder vindt u de wetenschappelijke publicaties van het Navigatie Lab Leiden

Het LIBC is actief betrokken bij training & onderwijs op het gebied van hersenen en cognitie.

Factoren van invloed op arbeidsparticipatie onder mensen met multiple sclerose

Ontdek de cursus "Survival Analysis (Advanced Biostatistics)" van Boerhaave Nascholing en leer over verbindend medisch leiderschap. Lees hier meer!

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

In het Leids Universitair Behandel- en Expertise Centrum (LUBEC) werken Klinisch (neuro)Psychologen, GZ-psychologen en Orthopedagoog-Generalisten. Zij bieden multidisciplinaire diagnostiek op maat.

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

Promotor: Prof.dr. G.P. van Wezel

Cardiovascular syndromes are the major cause of death in Western societies.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Promotor: Prof.dr. E. F. van Dishoeck

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Promotor: A.W. van der Vaart

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Promotor: Prof.dr. T. Schmidt

Politicologische studie naar de opzet, samenstelling en het functioneren van parlementaire commissies.

Jan Sleutels is een Universitair hoofddocent aan het Instituut voor Wijsbegeerte.

This course explains the functions of each international court and tribunal in The Hague. On the basis of cases and interviews with judges and lawyers, this course explores the role of these courts and tribunals and their potential to contribute to global justice.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Heart failure is a major health care problem with high mortality.

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Promotor: Prof.dr. J. den Hertog

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.