Promotor: Prof.dr. G.J. Kroes

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Creating a framework to assess the sustainability of fish farms which will set sustainability standards and give consumers information about the the sustainability and safety of their seafood.

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The aim of this project was to estimate emissions from lead products-in-use for the past, the present and the future and assess the development of toxicological risks associated with these products.

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Possible improvements for the assessment of abiotic depletion in LCA.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

De in de introductie geschetste ontwikkelingen leiden ertoe dat huishoudens meer verantwoordelijk gaan dragen voor sociale risico’s, meer zelf moeten plannen, over een langere periode en onder meer onzekerheid.Dit geldt niet alleen in Nederland, maar ook in andere westerse landen. Dit leidt tot de onderstaande…

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

An overview is given of the flows of chlorine and chlorinated hydrocarbons through the Europian Union.

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

In this study the flows of PVC and its additives through the Swedish Society were followed from the cradle to the grave (from production to waste treatment).

Examining the sustainability aspects of biotechnology, especially those related to the production of ethanol from biomass.

Description of Atlas of the surfacewater concentrations of pesticides in the Netherlands, a pilotstudy.

Description of 20th century changes in the Dutch flora: Description and interpretation (1999 - 2005)

Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?

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Promotor: G.A. Persoon, Co-promotor: H.H. de Iongh

Are there significant differences among the environmental impacts resulting form the production of Asian aquaculture commodities and what are the main causes for these?

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Accumulation of metals in economy and environment and its associated risks, within the Netherlands and the EU.

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Fundamental research in the ALgebra, Geometry And Number Theory

Promotor: M. Ubbink, Co-promotor: G. Siegal

Promotor: Prof.dr. W.J.G.M. Peijnenburg

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

This book aims to be a point of reflection and debate for journalists, academics and students to recognize a fundamental task in the duty of the communications professional, which is to influence through their daily work and their routines in order to achieve a more inclusive and plural society, through…

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.