In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Promotor: Prof.dr. J. Schaye, Co-promotor: Marcello Cacciato

Kevin speelt hedendaags repertoire dat zich onderscheidt doordat de lichamelijk handelingen die nodig zijn om deze muziek uit te voeren in de notatie van elkaar losgekoppeld zijn. Dit heet ook wel physical polyphonic notations, een unieke en relatief recente trend in de muziek waarbij naast de noten…

Bij Leiden University College The Hague staan Global Challenges centraal. Global Challenges zijn de grote, maatschappelijke uitdagingen van de 21ste eeuw waar we gezamenlijk een oplossing voor moeten vinden, zoals klimaatverandering, armoede, ongelijkheid, vrede en recht. Onze opleiding is opgesplitst…

This thesis has shed light on some of the ways in which the local electrolyte composition can differ from the bulk and how these changes in the local reaction environment can determine the activity and/or selectivity of two important electrocatalytic reactions, namely, electrochemical CO2 reduction…

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

Promotor: G.J.B. van Ommen

Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…

Promotor: J. Schaye

Promotor: G.P. van Wezel

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Bicarbonate buffer is largely found in nature due to its ability to regulate pH variations around neutral values. As the pH changes, so does the speciation of the buffer.

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

In this thesis, I studied the origin and evolution of the non-thermal radiation in merging galaxy clusters.

Promotor: J. Kuiper

In this article, Samuels focuses on the active fostering of subjunctivity in processes of narrative worldmaking. Drawing extensively from the narrative of an HIV‐positive woman in Indonesia, she shows that by subjunctively leaving open multiple narrative trajectories and future possibilities, individuals…

In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

Promotores: G. Persoon, R. Schefold

The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Hoogleraar Claartje Levelt is een internationaal erkend expert op het gebied van taalverwerving bij jonge kinderen. Ze onderzoekt hoe baby’s en peuters leren praten. Wie is Claartje Levelt?

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Promotor: J.W.M. Frenken

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

Lezing

This course provides an insider perspective into the work of international criminal courts and tribunals. You will learn about the investigation and prosecution of international crimes in The Hague.

Bij Cambridge University Press (CUP) verscheen onlangs van Ingrid Leijten het boek Core Socio-Economic Rights and the European Court of Human Rights. Het boek maakt onderdeel uit van de serie Cambridge Studies in European Law and Policy en heeft als onderwerp de bescherming van sociaaleconomische rechten…

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

Hoe is het om elke dag met de top uit jouw werkveld te werken? International Studies-alumnus Niels Drost weet daar alles van. Hij werkt momenteel als junior onderzoeker aan het Clingendael Instituut.

De specialisatie Politics, Culture and National Identities, 1789 to the Present (research) van de Universiteit Leiden brengt je in de voorhoede van de nieuwe benadering van de manier waarop in Europa politiek en identiteit worden opgevat.

We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.

Promotores: S.J. Edixhoven, F. Andreatta

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

Promotor: Prof.dr. C.W.J. Beenakker

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich