In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Het begrijpen van individuele verschillen in zelfregulatie bij jongens met ODD/CD op het niveau van het brein, cognitie en gedrag

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Graphene nanoribbons (GNRs) are used as a current carrying substrate in investigation of current-induced forces in a low-temperature STM (chapter 2).

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

This thesis aims to investigate the effect of tripartite interaction between microbial inoculants, the plant, and herbivore insects on the rhizosphere microbiome and volatilome. We investigated the rhizosphere microbiome and volatilome of tomato plants exposed to insect herbivory and/or inoculated with…

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Alumni-activiteit, New York

Van 2 tot 5 september 2015 is Leiden het toneel van een van de grootste linguïstische congressen ter wereld: de Societas Linguistica Europaea (SLE) Annual Meeting 2015. Hoe heeft Leiden zo'n prominente positie binnen de Taalkunde gekregen? Een gesprek met taalwetenschapper Arie Verhagen.

Lezing

Als alumnus van de Universiteit Leiden kunt u uw hele leven lang gebruik blijven maken van de Universitaire Bibliotheken Leiden (UBL).

Geïnteresseerd in Area Studies? Dan is Leiden the place to be! Meld je aan voor onze Online Area Studies Week van 2-5 juni en ontdek welke master bij je past.

Moritz Jesse has been awarded a Jean Monnet Chair by the European Commission. In his MIND-EU Project he will focus on a coherent way to teach Migration, Integration, and Non-Discrimination at Leiden Law School at bachelor and master level.

Geesteswetenschappen, Centre for Linguistics

Geesteswetenschappen, Centre for Linguistics

Ragazzi, ‘Suspect community or suspect category?‘, Journal of Ethnic and Migration Studies

Around the world, mindfulness has become big business. This course combines conventional scholarly inquiry from multiple disciplines with experiential learning to provide a responsible, comprehensive, and inclusive education about mindfulness as a contemporary phenomenon.

Quantitative biology means exploiting mathematical modelling and computer simulation as a tool to gain additional insights into the meaning of experimental data. Discover in this minor when and how to apply these tools, in a multidisciplinary setting.

Het boek

Lezing

Wouter Staal is benoemd tot bijzonder hoogleraar aan het instituut Pedagogische Wetenschappen in Leiden. De Karakter-leerstoel is gericht op autisme spectrum stoornissen: neurobiologie, neurocognitie en behandeling.

Meepraten over de toekomst van het advocatenkantoor als onderneming!

From Incident to Precedent

In this dissertation several settings in the Online Learning framework are studied. The first chapter serves as an introduction to the relevant settings in Online Learning and in the subsequent chapters new results and insights are given for both full-information and bandit information settings.

In this course, we will focus on the fascinating history of the Arabic Medieval World. We will take you on a journey through the Middle Ages. All along, we will present you with historiographical debates and dilemmas and travel back and forth in time explaining to you how events of the past affected…

Indo-European is the name of the language family to which English belongs, along with many sub-families such as Germanic languages and Romance languages. In this course, you will delve into the structure and origins of these branches, the oldest languages belonging to the language family, linguistic…

Promotie

Promotie

Promotie

Promotie

Promotie

Van 27 februari tot 1 maart 2018 namen studenten uit vier verschillende universiteiten deel aan de interuniversitaire workshop “A future for EU” (F4EU) in het Belgische Luik.

Ruim zeventig promovendi uit Leiden en Delft kwamen op 13 juli bijeen op het strand van Katwijk voor een workshop van de Casimir Research School: ‘So you have a degree in Science. Now what?’

Description of 20th century changes in the Dutch flora: Description and interpretation (1999 - 2005)

Analytical tools for environmental design and management in a systems perspective. The combined use of analytical tools.

Het masterprogramma is officieel geopend door Z.E. Kees Klompenhouwer, de Nederlandse Ambassadeur in Tsjechië.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…

Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Can we distinguish the effects of pesticides from other abiotic and biotic factors that occur in the field? And how do these factors interact with pesticides?