Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Het zinnetje ‘ijs en weder dienende’ is een goed voorbeeld van de zogenoemde deelwoordconstructie en misschien wel een van de meest ondoorgrondelijke van het Nederlands. Want wat (of wie) dient nu wie (of wat)? De betekenis is eigenlijk ‘als het ijs en weer meezitten’. De oratie van Gijsbert Rutten,…

Prof.dr. Niels Schiller is experimenteel taalwetenschapper. Hij houdt zich bezig met verwerkingsprocessen van taal in de hersenen en werkt nu aan een videobril voor doven en slechthorenden.

Het ligt misschien niet echt voor de hand, maar het Nederlands is na het Engels waarschijnlijk de best onderzochte taal ter wereld. Al die grammaticale kennis wordt nu gebundeld in een website: TaalPortaal.

Development of an aggregated impact indicator to measure decoupling.

Sinoloog en gastconservator van het Taalmuseum Jeroen Wiedenhof vertelt Sleutelstad FM over Vol van karakter, een expositie die aan de hand van unieke én alledaagse voorwerpen laat zien hoe Chinezen met taal omgaan.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

This paper describes the development process of voting behavior in Chile; particularly the relationship between the class voting theory and the theory of cultural post-materialist vote is investigated. This research deals with Chile as a case study, a developing country with a relatively stable democracy…

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

Kim de Jong, Jaime Delgadillo en Michael Barkham bieden waardevolle inzichten in hun boek 'Routine Outcome Monitoring and Feedback in Psychological Therapies' over hoe therapeuten en stagiaires feedback kunnen gebruiken om beslissingen over behandelingen te onderbouwen en uiteindelijk de resultaten…

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Promotor: G.R. de Snoo

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

The use of increasingly large and diverse datasets to guide urban climate action has implications for how, and by whom, local governments are held accountable.

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Promotor: R. Gill, Co-promotor: P. Massart

Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

The combination of data science and sports is a hot topic. In a talk during the opening of the Academic Year at the Faculty of Science, Professor Joost Kok explained what data analytics can teach us about sports.

Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.

De Leiden Science Run 2019 staat in het teken van Scholars at Risk, een programma van Stichting voor Vluchteling-Studenten UAF. Dit programma biedt bedreigde wetenschappers de mogelijkheid om hun onderzoekswerk tijdelijk voort te zetten in een veilige academische omgeving.

Op 20 februari 2019 vond een bijzondere bijeenkomst over data science plaats in de Tweede Kamer. De doelstelling van de bijeenkomst was om met overheidsorganisaties in dialoog te gaan over dataontwikkelingen binnen de overheid.

1) Assess the trends in supply and production status of these critical minerals and mineral products worldwide and Europe’s dependence including on intermediate products such as permanent magnets, RE based super alloys, batteries, polishing compounds, phosphors, catalysts etc. 2) Trace the entire value…

Laboratory, observation and modeling work on the dissociation of polycyclic aromatic hydrocarbons in interstellar environments and the formation of new molecular species through the fragmentation process.

De masterspecialisatie Politics, Society and Economy of Asia van de Universiteit Leiden is gericht op studenten die één of meer landen of regio’s van modern of hedendaags Azië willen bestuderen vanuit het perspectief van de sociale wetenschappen.

De masteropleiding Politics, Culture and National Identities, 1789 to the Present van de Universiteit Leiden geeft je de mogelijkheid om op een nieuwe manier Europese politiek en identiteit te onderzoeken.

De masterspecialisatie History, Arts and Culture of Asia van de Universiteit Leiden is gericht op studenten die één of meer landen of regio’s in pre-modern, modern of hedendaags Azië willen bestuderen vanuit de geesteswetenschappen.

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

This thesis focuses on the study of transient and variable radio sources in the universe.

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

This thesis explores interfacial conductance and electric field-effects in LaAlO3/SrTiO3 heterostructures.

This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.

Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros