Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

Studievoorlichting

Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Dit artikel onderzoekt de oorzaken en onderzoekt hoe verschillende publieke percepties van de rechtsstaat bijdragen aan deze trend.

Wouter Jong en Hanne Goossen onderzoeken de werkwijzen op het gebied van risico- en crisiscommunicatie binnen de toeristische sector.

Kiemproject: Hoe kunnen metaforen bijdragen aan betere maatschappelijke betrokkenheid bij quantumwetenschap en -technologie, en welke factoren beïnvloeden de acceptatie of weerstand tegen metaforen bij zowel experts als leken?

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

De masterspecialisatie Philosophical Perspectives on Politics and the Economy van de Universiteit Leiden was voorheen bekend onder de naam Philosophy, Politics and Economics.

We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

Promotor: J. Zaanen, Co-Promotor: V. Juricic

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Bij de Onderzoeksgroep Geweld en Geweldpreventie (Violence and Violence Prevention) wordt onderzoek gedaan naar de complexiteit van hedendaags geweld, de uiteenlopende verschijningsvormen ervan en strategieën voor preventie.

De ontwikkeling en versterking van sociale rechten en rechten van arbeiders in Indonesië weerspiegelt de bredere processen van sociale en politieke hervormingen in het land.

De incubatietijd (van infectie tot de eerste symptomen) en latente periode (van infectie tot de start van besmettelijkheid) zijn cruciaal voor het informeren van controle maatregelen aan het begin van een infectieziektenuitbraak. Een voorbeeld is de duur van quarantaine voor potentieel geïnfecteerden,…

Hoe helpen demonstratie-experimenten in de klas leerlingen om te leren chemisch redeneren?

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Development of an aggregated impact indicator to measure decoupling.

This paper describes the development process of voting behavior in Chile; particularly the relationship between the class voting theory and the theory of cultural post-materialist vote is investigated. This research deals with Chile as a case study, a developing country with a relatively stable democracy…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Lezing, Symposium

Politieke stijl, het gehele optreden van politici, speelt steeds meer een rol en elke politicus kiest daarin zijn eigen manier. Carola Schoor, programmaleider Public Affairs bij het Centre for Professional Learning, vertelt erover in de Public Affairs Academie Podcast.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Kim de Jong, Jaime Delgadillo en Michael Barkham bieden waardevolle inzichten in hun boek 'Routine Outcome Monitoring and Feedback in Psychological Therapies' over hoe therapeuten en stagiaires feedback kunnen gebruiken om beslissingen over behandelingen te onderbouwen en uiteindelijk de resultaten…

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)

Promotor: G.R. de Snoo

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

The use of increasingly large and diverse datasets to guide urban climate action has implications for how, and by whom, local governments are held accountable.

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…