A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments

In this dissertation non-parametric Bayesian methods are used in the application of robotic vision.

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

Developing methodes to understand the evolution of patches in natural ecosystems

Review of new technical decisionsupport systems in the environmental field, and application in water management decission processes.

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

This initiative is intended to support generative research collaborations between and among scholars located in different geographical regions who wish to pursue focused, joint projects in any area of the study of religion.

Investigating the contribution of interpreters, informants, hunters and guides in the making of colonial scientific knowledge.

Wiskunde en Natuurwetenschappen

Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Promotor: Prof.dr. H.J.A. Rottgering

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.

Promotor: Prof.dr. L.J. Slikkerveer

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

Consequences for sediment stability and seston trapping

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Identification of the products or product groups that have the greatest environmental impact from a life-cycle perspective using environmentally extended input-output analysis.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Promotor: G.P. van Wezel

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Promotor: T.H. Oosterkamp

Promotor: W. Jiskoot, Co-promotor: H.A. Every

This dissertation consists of two parts, with the common theme

Promotor: Prof.dr. M. Danhof

Promotor: Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Univ. de Bordeaux)

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

Promotor: K.J. Batenburg

Stellar feedback is a crucial ingredient in the evolution of galaxies.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.