Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

How to contribute to a quantum leap of eco-industrial symbiosis in China?

Twee hoogleraren die op dezelfde dag hun oratie uitspreken, dat is een zeldzaamheid aan de Universiteit Leiden. Berna Güroğlu en Ellen de Bruijn zijn gespecialiseerd in aanverwante vakgebieden: beiden onderzoeken de invloed van sociale context op hersenprocessen. Güroğlu doet dat bij adolescenten, De…

Promotores: F.H.J. Redig, W.T.F. den Hollander

Op 21 maart 2019 verdedigde James Welch zijn proefschrift 'The Grotius Sanction: Deus Ex Machina. The legal, ethical, and strategic use of drones in transnational armed conflict and counterterrorism'. Het promotieonderzoek is begeleid door promotor prof. dr. P.B Cliteur.

Op 23 oktober 2019 verdedigde Yoram Stein zijn proefschrift 'Spinoza's Theory of Religion: The Importance of Religion in Spinoza's Thought and Its Implications for State and Society'. Het promotieonderzoek is begeleid door promotor prof.dr. P.B. Cliteur en prof.dr. A.A.M. Kinneging.

How to bring together different footprints into an integrated family and what are the synergies? What are the roles of inventory analysis and characterization in measuring individual footprints and how these affect a footprint family? How to benchmark environmental footprints against related planetary…

Engelsen hebben een groot normbesef als het gaat om taal: in formele situaties hoor je beschaafd Engels te spreken. Toch zijn de meesten tijdens het dagelijks taalgebruik wel een stukje milder in hun oordeelen bepaalde zinsconstructies te vermijden. Dat blijkt uit een onderzoek van taalkundige Carmen…

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

In his dissertation Michiel Hooykaas outlines the results of six empirical research projects focused at biodiversity awareness in the Netherlands, specifically people’s knowledge about animals.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

This thesis consists of three papers that are centered around the common theme of Hausdorff uo-Lebesgue topologies and convergence structures on vector lattices and on vector lattices and vector lattice algebras of order bounded operators.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Promotor: Prof.dr. E. Smets, M. Stech

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

The radio sky harbours both galactic and extragalactic sources of arcminute- to degree-scale emission of various physical origins. To discover extragalactic diffuse emission in the Cosmic Web beyond galaxy clusters, one must image low–surface brightness structures amidst a sea of brighter compact fore-…

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

Studievoorlichting, Online Experience

How do nanoparticles bioaccumulate and biodistribute in organisms?

Promotor: M.A.G.J. Orrit

We present an extensive study of methods for exactly solving stochastic constraint (optimisation) problems (SCPs) in network analysis. These problems are prevalent in science, governance and industry.

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

Beleid dat erop is gericht radicalisering tegen te gaan, ondermijnt het vertrouwen en de sociale cohesie binnen onze samenleving.

Dit artikel onderzoekt de oorzaken en onderzoekt hoe verschillende publieke percepties van de rechtsstaat bijdragen aan deze trend.

Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

LIACS is a partner in the EU Erasmus+ Curriculum Development for the Asian education system. The knowledge available in the field of Data Science and Artificial Intelligence education will be shared and adapted for the Asian market.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

Promotor: Prof.dr. J.P. Abrahams

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.