Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

Promotor: J.M. van den Broek Co-promotor: M.C. de Vries

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

In 2005 en 2015 heeft de Leiden University Academy of Creative and Performing Arts twee eredoctoraten toegekend.

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Om de juiste klinische beslissingen te nemen of effectieve diagnostische testen en behandelingen te kunnen ontwikkelen, is het belangrijk om de onderliggende mechanismen van een aandoening of een bepaald gedrag te begrijpen.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

In films kunnen de meest wonderlijke acties plaatsvinden. Maar zijn die acties in de 'echte' wereld ook mogelijk? En in hoeverre houden filmmakers ons voor de gek? Tijdens het Leiden International Film Festival komen film en wetenschap samen.

Development of GHG calculator for bio-electricity and heat.

This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

Promotor: F.J. van Lunteren, E. Jorin

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

Sterrewacht Leiden is het sterrenkundig instituut van de Faculteit der Wiskunde en Natuurwetenschappen van de Universiteit Leiden.

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: M. Haverkorn

Promotores: J. Kok, M. Chaudron (Chalmers University)

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Was de progressieve koloniale bestuursambtenaar de voorloper van de post-koloniale ontwikkelingswerker?

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

Het Leiden Leadership Centre verbindt wetenschap en praktijk door evenementen over publiek leiderschap te organiseren – zoals Leiden Leadership Lunches, webinars, (internationale) conferenties en de Leiden Leadership Podcast.

An important part of the SCS specialisation is the internship period. Students will get the opportunity to get to know the field and to apply what they have learned during the courses.

Beleef en ervaar de materiële aspecten van middeleeuwse manuscripten, geannoteerde boeken, prenten, tekeningen en fotoalbums tijdens een van de vele activiteiten.

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

De gratis online academische cursussen van de universiteit zijn voor iedereen over de hele wereld te volgen.

To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.

Studievoorlichting

Studievoorlichting

Studievoorlichting

Martin Richardson, die in 1997 afstudeerde aan het toenmalige Leiden LLM Programme in European Community Law (nu: Leiden Adv LLM European and International Business Law, EIBL), is onlangs benoemd tot Senator van het College of Justice in Schotland. Dat betekent dat hij nu rechter is van de hoogste civiele…

De ontdekking dat elf planetoïden mogelijk met de aarde zullen botsen is wereldnieuws. Het onderzoek van drie Leidse sterrenkundigen verscheen wereldwijd op meer dan 190 nieuwssites, van Amerika tot China. Ze ontwikkelden en trainden hiervoor een kunstmatig neuraal netwerk.

Sociale Wetenschappen, Psychologie

Faciliteiten waar LIBC leden gebruik van kunnen maken (in het Engels):

Between the early thirteenth and early sixteenth centuries CE, the Sultanate of Cairo affected the balances of power elites across and beyond the regions of Egypt, Syria and the Eastern Mediterranean. Modern historiography has for a long time been determined by the idea of this sultanate as a highly…

Hoe meer mogelijkheden een kind krijgt om te leren en zich te ontwikkelen, hoe sterker zijn of haar positie in de maatschappij zal zijn. De Universiteit Leiden onderzoekt hoe de hersenen informatie oppakken, en hoe leerprocessen positief kunnen worden beïnvloed.

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)