This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Promotor: Prof.dr. P. Stevenhagen, Co-promotor: B. de Smit

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

Promotor: B.van de Water, Co-promotor: L.S.Price

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

Guest lecture

This interdisciplinary study focuses on (trans)national ethnic and popular networks, combining historical-ethnographic and computational methods to understand the ‘workings’ of networked conflict interfering in the increasingly violent conflict in the Sahel (Africa) and beyond. The project focuses on…

This programme aims to make the digitized archival sources of the Kerala and Tamil Nadu Archives more accessible to Indian and international scholars and to the widest possible audience, in particular to the people of Kerala.

This thesis studies the geometry of representation varieties and character stacks. These are spaces parametrizing the representations of a finitely generated group, typically the fundamental group of a compact manifold, into an algebraic group G.

In oktober werd Sophie Starrenburg gekozen tot lid van het coördinerende comité van de ESIL ‘Interest Group on the International Law of Culture’. Ze zal hierin samenwerken met Giovanni Carlo Bruno (Italian National Research Council), Andrzej Jakubowski (Polish Academy of Sciences) en Lucas Lixinski…

This Spring School will pay attention to a wide range of performances in history, from political gatherings, religious rituals, and courtroom proceedings to theatre, concerts, and dance. It combines a focus on the medieval and early modern period with an interdisciplinary perspective, attending to the…

Candidates are invited to submit their ‘own proposals for doctoral projects, which can come from the following eleven subjects: Ancient History, Old Testament, Ancient Oriental Studies, Christian Archaeology and Byzantine Art History, Greek Studies, Historical-Comparative Linguistics, Classical Archaeology,…

Pulpnieuwssites met onbekende namen als Trendnieuws en Viraal Vandaag bereiken dankzij hun Facebookpagina’s miljoenen Nederlanders. Berichten van die pagina’s worden veel vaker gedeeld en geliket dan berichten van pagina’s van bekende nieuwsmedia als De Telegraaf, NOS en NU.nl. Dat blijkt uit onderzoek…

Via een open oproep zocht Museum De Lakenhal creatieve oplossingen voor het probleem van groeiverslaving. Uit ruim 500 inzendingen zijn 15 kunstwerken geselecteerd voor de expositie 'If things grow wrong'. Ook de creaties van de Leidse wetenschappers Peter van der Putten en Evert Jan van Leeuwen zijn…

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De Faculteit der Geesteswetenschappen richt zich in onderzoek en onderwijs op verschillende wetenschapsdisciplines en op de mobiliteit van mensen, taal, cultuur, ideeën, kunst en instellingen in een globaliserende wereld in hun onderlinge samenhang door de eeuwen heen. Dit vormt ook de basis voor de…

Sociale veerkracht en veiligheid zijn urgente onderwerpen in onze samenleving. De COVID-19-pandemie heeft grote impact gehad op onze levens, zowel op persoonlijk als sociaal vlak. Het aantal mensen dat last heeft van stress, eenzaamheid en afgenomen kwaliteit van leven, is toegenomen. Ook zijn…

Hifadhi ya Dijiti ya Ustadh Mau

Te dure boodschappen, plotseling uitbrekende ziekten: vanaf de zestiende tot de negentiende eeuw doen honderden mensen verslag van de wereld om hen heen in kronieken. Een groot deel van deze teksten is de afgelopen jaren gedigitaliseerd. Hoogleraar Vroegmoderne Nederlandse Geschiedenis en projectleider…

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Het Institute of Security and Global Affairs (ISGA) van de Faculteit Governance and Global Affairs nodigt hierbij iedereen van harte uit om mee te denken en te doen tijdens de internationale ISGA Conferentie 'Who determines the security (research) agenda?' op 9-10 november 2016 in het New Babylon Meeting…

The Medieval Academy of America (MAA) is excited to announce the launch of a new Summer Research Program for early PhD or early PhD-track students. The 2022 Summer Research Program will convene over Zoom, over the course of six weeks in July and August. The Summer Research Program will culminate with…

ILS organizes a new lunch seminar series where all researchers from Leiden Law School can present their research. The idea is to hear in a simple and nice way what researchers from other research programs and institutes are working on. During a seminar two or three speakers will present their research.…

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Onderzoekreeks van de Afdeling Economie van de Universiteit Leiden op het raakvlak van economie en recht.

De onderzoeksgroep Business, Technology & Public Policy van de afdeling Bedrijfswetenschappen van Universiteit leiden houdt zich bezig met het onderzoeken van de dynamische wisselwerking tussen ‘nieuwe’ technologieën en de verschillende belanghebbenden die hiermee interacteren, waaronder consumenten,…

Publicaties die verschijnen in het kader van het onderzoeksproject Zelfredzaamheid en sociale bescherming over de levenscyclus.

Promotor: Prof.dr. H.S. Overkleeft

The key purpose of this project is to study tautological relations on the level of closed differential forms or even integral cochains (i.e. we don't take classes in cohomology).

When observing star-forming galaxies, we are not only seeing stellar light, but we also see how this interacts with galactic gas and dust. This thesis contains studies of the stellar, nebular and dust properties of low mass star-forming galaxies.

We have conducted a full spectral line survey of the 3-13 micron region of two massive protostars, AFGL 2591 and AFGL 2136, for the first time at high spectral resolution.

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

Promotor: Bas Edixhoven, Promotor: Qing Liu

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…