7,534 zoekresultaten voor “Research” in de Publieke website
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Reverse engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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Quantum dot microcavity control of photon statistics
During my PhD research, I studied the photon statistics of light emitted by a microcavity that contains a single quantum dot (QD) on resonance.
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Implementation of the EU Preventive Restructuring Directive Part I
In 2019 hebben het Europees Parlement en de Raad de Richtlijn Preventieve Herstructurering (2019/1023) aangenomen, die voorziet in minimale harmonisatie van onder andere preventieve herstructureringskaders (preventive restructuring frameworks, 'PRF'). Dit boek biedt verdiepende analyses van de implementatie…
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Coiled-coils on lipid membranes: a new perspective on membrane fusion
Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros
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PEERS
In dit project wordt gekeken naar kinderen en hun relaties met leeftijdsgenoten. We willen daarbij graag meer te weten komen over het welzijn van kinderen en hoe dit gelinkt is aan onderwerpen zoals vriendschappen, angst en sociale vaardigheden. Door naar deze onderwerpen en hun samenspel te kijken,…
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A new method to reconstruct the structure from crystal images
Promotor: J.P. Abrahams, Co-promotor: T. Grüne
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Efficient constraint multi-objective optimization with applications in ship design
Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Structural Health Monitoring Meets Data Mining
Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe
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Evolvability and epistasis studied through the lens of an antibiotic resistance enzyme
Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Structure dependence of molecular reactions on surfaces
The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
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Evaluatie Wet homologatie onderhands akkoord
Dit boek bevat het rapport van het evaluatieonderzoek van de Wet homologatie onderhands akkoord (WHOA) uitgevoerd door een onderzoeksteam van de Rijksuniversiteit Groningen en de Universiteit Leiden in opdracht van het Wetenschappelijk Onderzoek- en Datacentrum (WODC). De WHOA geeft levensvatbare bedrijven…
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Unraveling the drivers of antimicrobial pharmacokinetic variability in individuals with obesity and hospitalized patients with multimorbidity
Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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Exploring charge transport properties and functionality of molecule-nanoparticle ensembles
Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen
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De intieme stem van de Russische Avant-garde: het aanpassen van het esthetische zelf en de opkomst van het Socialistisch Realisme
This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.
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Onderzoek
Onderzoek aan LUC past binnen het algemene kader van de wereldwijde uitdagingen die centraal staan in ons onderwijsprogramma. Het richt zich op belangrijke maatschappelijke vraagstukken, waaronder Vrede & Recht, Diversiteit, Welvaart en Duurzaamheid.
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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Bakti and Sayan traditions among the Tenggerese people in East Java: the role of indigenous institutions in integrated elderly care development
This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…
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Atomic Insights into Hydrodesulfurization
Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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Lost in translation: The toll-like receptor 7 induced pharmacological challenge model of the skin
This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.
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Non-invasive biomarkers for inflammatory skin diseases: towards systems dermatology
Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…
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‘The Eurasian Question’: The postcolonial dilemmas of three colonial mixed-ancestry groups compared
Waarom kozen sommige Euraziërs ervoor in de voormalige kolonie te blijven, terwijl anderen naar de metropool of een ander land vertrokken?
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Matchmaking for open innovation: perspectives on multi-sided markets
Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)
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Onderwijs
De programmagroep Leer- en Gedragsproblemen in het Onderwijs is verantwoordelijk voor onderwijs op het gebied van leerproblemen binnen de bachelor- en masteropleidingen van het Instituut Pedagogische Wetenschappen.
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A search for transient reductions in the speed of sound of the inflaton in cosmological data, and other topics
Promotor: Prof.dr. A. Achucarro
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Environmental sustainability of NdFeB magnet recycling: foresight study on recycling systems and technologies
The demand for neodymium-iron-boron (NdFeB) magnets is rapidly growing, while the neodymium supply chain is under pressure. Recycling can alleviate these issues. This thesis investigates the potential for deploying novel magnet recycling technologies and their environmental consequences.
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Activiteiten
Maak kennis met de wetenschap via deze activiteiten bij de universiteit of op school.
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Luminescence and applications of lanthanoid coordination polymers
Promotor: E. Bouwman, Co-Promotor: S. Bonnet
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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Subjectieve ervaringen van de bijwerkingen van methylfenidaat bij jongeren
Het doel van dit onderzoek is om de bijwerkingen tijdens de behandeling met methylfenidaat in kaart te brengen en te onderzoeken hoe kinderen het gebruik van het medicijn (zoals Ritalin, Concerta en Medikinet) ervaren.
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Betekenisgeving en informatie-integriteit in het tijdperk van AI
Hoe verandert generatieve AI de manier waarop we leren, communiceren en de wereld van vandaag begrijpen? Nu AI-tools deel uitmaken van het dagelijks leven, produceren ze niet alleen tekst, maar geven ze ook betekenis, beïnvloeden ze vertrouwen en hebben ze invloed op hoe we informatie vinden en delen.…
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Docenten
Docenten die betrokken zijn bij deze opleiding zijn:
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Onderwijs
Het onderwijsprogramma van Clinical Psychology is gericht op het verkrijgen van gespecialiseerde kennis van psychopathologie, diagnostische- en behandelvaardigheden en daaraan gerelateerd wetenschappelijk onderzoek.
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Microphysiological liver systems for in vitro modeling and industry implementation
This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.
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Using cryo-EM methods to uncover structure and function of bacteriophages
Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.
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Learning in Automated Negotiation
This dissertation advances automated negotiation by developing agents that can learn and adapt across diverse negotiation settings through three increasingly sophisticated approaches: automated algorithm configuration, portfolio-based strategy selection, and end-to-end reinforcement learning with graph…
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Pollinators in complex landscapes Modelling and mapping the distribution of wild bees and hoverflies in the Netherlands
This thesis explores how bees and hoverflies are distributed across the Dutch landscape and how ecological and landscape factors shape their occurrence.
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Doorstroom naar de masteropleiding
Voor de toelating tot de masteropleiding per september 2026 moet je je aanmelden via Studielink. Je moet opnieuw een toelatingsverzoek indienen, ditmaal voor toelating tot de MSc Psychology. Dit toelatingsverzoek moet 15 mei 2026 binnen zijn. Voor de masteropleiding die begint in februari 2027 is dat…
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Veilig voor de melder: Rapport Invoeringstoets Wet bescherming klokkenluiders
Dit boek bevat het rapport over de Invoeringstoets van de Wet bescherming klokkenluiders (de Wbk) uitgevoerd door een onderzoeksteam van SEO Economisch Onderzoek en de Universiteit Leiden in opdracht van het ministerie van Binnenlandse Zaken en Koninkrijksrelaties.
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SAILS Lunch Time Seminar: Flor Miriam Plaza del Arco
Lezing
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SAILS Lunch Time Seminar: Friso Selten
Lezing
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Spectral signatures of breaking of ensemble equivalence
This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…
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Onderzoek
Het onderzoek van de afdeling Economie is ondergebracht bij meerdere facultaire programma's. Het onderzoek van de afdeling richt zich thans met name op sociaal-economische vraagstukken, rechtseconomie en fiscale economie.
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Survival of the Littlest: Improving Preterm Outcomes through Metabolomics and Microsampling
Preterm birth is a major contributor to neonatal morbidity and mortality and is associated with both acute complications and long-term health consequences.
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Urban green infrastructure for biodiversity and ecosystem services
Urbanisation is steadily increasing with estimates expecting that 68% of the global population will live in cities by 2050. To accommodate the rural to urban transition, large quantities of land are transformed from natural to urban lands.
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Over de opleiding
Deze eenjarige Nederlandstalige masterspecialisatie onderzoekt Nederland en zijn mondiale en koloniale context, vanaf de middeleeuwen tot nu.
