Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Factoren van invloed op arbeidsparticipatie onder mensen met multiple sclerose

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Een onderzoek naar moord en doodslag.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Promotor: J. Kuiper

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

Wie aan inlichtingenwerk denkt, denkt aan James Bond. De dagelijkse praktijk is gelukkig genuanceerder. In Vijandbeelden bespreekt Constant Hijzen het werk besproken van de Nederlandse inlichtingen- en veiligheidsdiensten, vroeger en nu.

Promotor: Prof.dr. J. Kuiper

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Promotor: F.S. de Boer Co-promotor: P. T. de Gouw

How does governing work today, and how does society handle pressing challenges in ways that are democratic, effective, fair, peaceful, and sustainable?

Psycholoog Bernadet Klaassens heeft een groot fMRI-onderzoek opgezet naar het effect van medicijnen op hersennetwerken bij veroudering en de ziekte van Alzheimer. Het leverde een unieke dataset op en zicht op een nieuwe methode om medicijnen te ontwikkelen voor patiënten met Alzheimer.

Op 28 juni 2018 verdedigde Qiuyin Hu zijn proefschrift 'Regulating Working Conditions in Times of Globalization'. Het promotieonderzoek is begeleid door promotoren prof.dr. G.J.J. Heerma van Voss en prof. dr. B. Barentsen.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

Dr. Helen Pluut heeft een artikel gepubliceerd in het gerenommeerde tijdschrift Organizational Behavior and Human Decision Processes (OBHDP). Dit in samenwerking met Remus Ilies (National University of Singapore), Petru Curşeu (Open Universiteit en Babeş-Bolyai University) en Yukun Liu (University of…

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Promotores: H.A. Udo De Haes, P.M. Brakefield

In this top-rated course, you will learn how the European Union prepares and decides on policy, and how policy is transferred to member states and implemented by various authorities. It discusses the challenges of the European multi-level governance structure and the main causes of policy failure or…

Investigating the contribution of interpreters, informants, hunters and guides in the making of colonial scientific knowledge.

Promotor: Prof.dr. J.W.M. Frenken

Op 9 juni 2020 verdedigde Maral Darouei haar proefschrift 'Managing a sustainable career in the contemporary world of work: Personal choices and contextual challenges'. Het promotieonderzoek is begeleid door promotor prof.dr. J.I. van der Rest.

Bernard Bernards onderzoekt beperkingen op innovatie door te focussen op cognitieve onzekerheid als toestand die innovatief werkgedrag kan beïnvloeden.

Hoewel de meerwaarde van stages in het bedrijfsleven in eerder onderzoek wordt onderschreven, is er nog niet veel bekend over hoe het leren van docenten tijdens hun stage plaatsvindt en hoe zij hun leerervaringen uit stages gebruiken voor hun nderwijs. Om een meer diepgaand inzicht te verkrijgen in…

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

De discussie over inzetbaarheid van afgestudeerden in het hoger onderwijs bestaat al een aantal jaren. Toch staan ​​universiteiten nog steeds voor de uitdaging om afgestudeerden te leveren die aan de verwachtingen van het bedrijfsleven kunnen voldoen.

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Cardiovascular syndromes are the major cause of death in Western societies.

Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Promotor: Prof.dr. J. Kuiper

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Promotor: S.M. Verduyn Lunel

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.