Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Hoe heeft migratie de Ierse en Italiaanse samenleving sinds 1945 beïnvloed?

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Waarom zijn transnationale en interculturele agenten zoals Henrich Carloff en Willem Leyel belangrijk voor de studie van de vroegmoderne expansie?

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Hoe worden nachtruimtes verbeeld, geproduceerd, ervaren en verteld door migrantengemeenschappen in Europa? Dit onderzoeksproject onderzoekt deze vraag in acht Europese steden: Aarhus, Amsterdam, Berlijn, Cork, Galway, Lissabon, Londen en Rotterdam.

Het HOPES Onderzoek is een van de grootste onderzoeken van dit soort tot nu toe! Door bestaande hersenscans en gegevens van meer dan 4.000 jongeren tussen 14 en 25 jaar te bestuderen, hoopt het projectteam specifieke veranderingen in de hersenen te identificeren die jongeren kwetsbaar maken voor zelfmoordgedachten…

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Promotor: Prof.dr. L.J. Slikkerveer

Dit artikel geschreven door Marieke Liem & Alexander Kamprad onderzoekt de relatie tussen terrorisme en interpersoonlijk geweld. Ze voerden cross-nationale analyses uit over de effecten van mortaliteitscijfers voor het terrorisme op moordcijfers. Uit de resultaten bleek dat terrorisme sterk en positief…

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

The project

De Faculteit der Wiskunde en Natuurwetenschappen streeft naar impact van haar onderzoek en onderwijs op de samenleving. Daarvoor werkt de faculteit in binnen- en buitenland samen met andere universiteiten en instituten, maatschappelijke partners, het bedrijfsleven én met het brede publiek.

Did the Jochids leave their mark on the Grand Duchy, taking into account that the Lithuanian state was one of the main successor states of the Great Horde in the 16thCentury?

Congres/symposium

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Lezing

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

De Leiden Slavery Studies Association (LSSA) is toegewijd aan het bevorderen van een beter begrip van slavernij en post-slavernij in elke periode en elk geografisch gebied.

Medewerkers van de sectie Methodologie & Statistiek zijn lid van verschillende commissies.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Leiden University’s Academic Challenge

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

This thesis advances automata learning, a key area in computer science, with applications in software verification, biological analysis, and autonomous technologies. It explores three main themes: first, it introduces a passive learning algorithm for generating compact probabilistic models from positive…

Onderzoeksgroepen in het Quantum Matter & Optics onderzoeksprogramma onderzoeken elektronische eigenschappen van interacties van materie en lichtmaterie, met de nadruk op quantuminformatie.

Promotores:Th.J.C. van Berkel, M. van Eck

We are living in an information era where the amount of image and video data increases exponentially.

De Una Europa Clusters brengen vooraanstaande deskundigen en ervaren personeelsleden van de talrijke academische en professionele diensten van de Una Europa -partners samen.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Bij LIACS erkennen we de groeiende behoefte aan geavanceerde technische ondersteuning bij onderzoeksprojecten en labonderwijs. Toenemende studentenaantallen, steeds geavanceerdere hardware en infrastructuur, nieuwe eisen rondom dataveiligheid en -beheer, en de complexiteit van de kerncursussen informatica…

In vroegmiddeleeuws Engeland was er belangstelling voor de geschiedenis van het Romeinse Rijk en koningen namen imperiale titels als 'imperator' en 'basileus' over. Hoe kunnen we deze interesse verklaren en welke functies hadden imperiale ideeën en de ontvangst van de klassieke wereld in vroegmiddeleeuws…

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

This thesis combines field and laboratory studies to address some of the most pressing questions in the field of microplastic research.

Wie is de economische mens? Elk economisch paradigma veronderstelt een antropologie, een theorie van de menselijke natuur. Dit onderzoeksproject gaat over de antropologieën die worden geïmpliceerd en geproduceerd door antieke Griekse economische teksten, en de specifieke kennisvormen waardoor deze antropologieën…

Kunnen we van quantum-verrassingen quantum toepassingen maken? Kunnen we het leven onderzoeken en opbouwen vanuit de nano-schaal?