This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Promotores: J. Jonkers, K.E. de Visser

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

Prof. Judith Bovée kreeg zaterdag een prijs uitgereikt op Zeldzame Ziektendag. De prijs is een blijk van waardering vanuit de gezamenlijke patiëntenverenigingen voor haar wetenschappelijk en diagnostisch werk op het gebied van zeldzame bottumoren.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Promotie

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Promotie

Promotie

Loopbaan en solliciteren

Read-Urban was een eerste project om te onderzoeken of beleidsaanbevelingen gedaan kunnen worden met behulp van linked dataverzamelingen en data science en om ervaring op te doen met de succesfactoren voor een dergelijk proces.

This dissertation presents a new perspective on the life, work and character of the Dutch physical chemist Jacobus Henricus van ’t Hoff, first recipient of the Nobel Prize in Chemistry, and one of the most important and colourful scientists in Dutch history. The image of Van ’t Hoff that emerges from…

This initiative is intended to support generative research collaborations between and among scholars located in different geographical regions who wish to pursue focused, joint projects in any area of the study of religion.

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.

Promotor: Prof.dr. G.P. van Wezel

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Promotor: Peter Stevenhagen

This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.

This thesis applies data mining in commercial settings in the telecommunications industry.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

This work is dedicated to interpreting in cohomological terms the special values of zeta functions of arithmetic schemes.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Promotor: J. N. Kok, Co-promotor: A. J. Knobbe

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Promotor: Roeland M.H. Merks

What is the best way to combine the environmental and economic data and how can we create an operational system to do so, thereby supporting the delivery of data to the Data centres on Products and Resources?

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…