The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Promotores: Prof. dr. G.R. (Geert) de Snoo, Dr. E. (Ester) van der Voet

OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

Sheltering is an immediate human need and determines well-being andhealth.

Plant diversity is essential for us and our planet as it sustains the stability of our ecosystems, provides vital materials and food to us and supports many ecosystem services.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek

This thesis aims to investigate the effect of tripartite interaction between microbial inoculants, the plant, and herbivore insects on the rhizosphere microbiome and volatilome. We investigated the rhizosphere microbiome and volatilome of tomato plants exposed to insect herbivory and/or inoculated with…

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.

Can we distinguish the effects of pesticides from other abiotic and biotic factors that occur in the field? And how do these factors interact with pesticides?

Promotor: Prof.dr. J. den Hertog

Cardiovascular diseases are still a major concern for the global health.

The expanding population and economic activity are driving up global energy consumption. Simultaneously, there is an urgent need to transition from fossil fuels to renewable sources to mitigate the climate crisis, primarily caused by fossil fuel combustion.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

Sustainable energy from wind and solar is most readily available near the sea.

Marian Klamer legt verdwijnende Austronesische en Papuatalen vast en werpt nieuw licht op de Indonesische geschiedenis.

This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

Promotores: H.A. Udo De Haes, P.M. Brakefield

Consequences for sediment stability and seston trapping

Dr. Marian Klamer, werkzaam binnen LIAS en LUCL, is een internationaal erkend expert op het gebied van de beschrijvende taalkunde. Vanuit haar specialisatie op het gebied van de Austronesische en Papua Taalkunde draagt zij bij aan bredere disciplinaire en interdisciplinaire ontwikkeling van de weten…

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

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Op 1 februari 2018 verdedigde Nathalie-Sharon Koster haar proefschrift getiteld ‘Crime victims and the police’. Het promotieonderzoek is begeleid door promotoren prof. dr. J.P. van der Leun en dr. mr. M.J.J. Kunst.

De masteropleiding Health, Ageing and Society bereid studenten voor op een betekenisvolle rol in het verbeteren van de kwaliteit van leven van ouderen, en de kwaliteit en organisatie van de zorg voor een verouderende samenleving. Onze studenten voelen zich sterk betrokken bij maatschappelijke vraagstukken…

In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…

Promotor: E. Gittenberger, Co-promotores: B.W. Hoeksema; L.P. van Ofwegen

Promotor: Prof.dr. C.U. Keller

Promotor: M.A.G.J. Orrit

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

Niet altijd werd in Japan Japans gesproken. Wetenschappers verbinden de komst van de taal naar Japan met de migratie van boeren rond 400 v. Christus. Taalkundige Elisabeth de Boer gaat met een ERC Starting Grant onderzoek doen naar de verdere verspreiding van de taal in Japan.

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Op 19 mei 2020 verdedigde Xuechan Ma haar proefschrift 'Moving towards Coexistence and Cooperation: The Spratly Islands and International Law'. Het promotieonderzoek is begeleid door promotor prof.dr. N.J. Schrijver.

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Houden en fokken van proefdieren voor onderzoeks- en onderwijsdoeleinden.

Exploring the Meanings of Lands and Forests as an Avenue for Mutual Development of People and Nature in Ghana

Onderzoeksgroepen in het Biological & Soft Matter onderzoeksprogramma ontrafelen de mechanismen in biologische processen en ontwikkelen nieuwe zachte materialen die geïnspireerd zijn door de natuur.