Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Fate and toxicity of copper nanoparticles was related to the water chemistry of the environment and pristine size.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Lezing

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Promotor: W.T. de Groot

Software development is a complex process. It is important that software products become stable and maintainable assets.

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Migration imposes special pressures on the meaning, experience and organization of lifecycle rituals. These pressures are felt most strongly by Muslim migrants to Western Europe. In this innovative study, Nathal M. Dessing examines the effects of migration on the life cycle rituals of Moroccan, Turkish…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

De onderzoeksgroep Business, Technology & Public Policy van de afdeling Bedrijfswetenschappen van Universiteit leiden houdt zich bezig met het onderzoeken van de dynamische wisselwerking tussen ‘nieuwe’ technologieën en de verschillende belanghebbenden die hiermee interacteren, waaronder consumenten,…

Integrating life cycle assessment (LCA) with life cycle costing (LCC) offers the opportunity to simultaneously analyze the environmental and economic aspects of product alternatives, for the integration of which a unified computational has been proposed by Heijungs et al. (2013) [1]. The project aims…

Do sustainability values play a role in motivating people to act for biodiversity in successful projects and in successful leadership action? And how could these values be incorporated in current economic valuation methods?

How are links between macro-invertebrate diversity and ecosystem functioning influenced by anthropogenic pressures?

The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.

What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Safety issues of the transport and storage of Chlorine, ammonia and LPG.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

Promotor: M. Ubbink, Co-promotor: G. Siegal

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?

The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.

The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.

Promotor: Prof.dr. A.G.G.M. Tielens

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

In light of climate change, it is crucial to determine whether plant species can adapt to future climates to avoid extinction. Plants adapt to various conditions by altering their functional traits, such as leaf size or photosynthetic rate. Some traits appear linked and vary together between species,…

Promotor: S.M. Verduyn Lunel

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Control of infectious diseases poses continuous challenges for human health.

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn