The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

De Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) viert 'International Day of Women and Girls in Science' 11 februari op twitter @NWOict met portretten van drie #WomeninScience, onder wie de Leidse neuropsycholoog Femke Nijboer.

Op zaterdag 9 februari 2019 vierden we de International Day of Women and Girls in Science 2019 in Leiden! Bekijk het fotoverslag van deze feestelijke dag, met bijdragen van Robbert Dijkgraaf en Ewine van Dishoeck, en tal van boeiende workshops en spannende experimenten.

As a member of the Research School you can take part in join-in courses. Join-in courses are MA-courses in medieval topics given in set MA-programs of the six participant universities of the Research School. These courses allow you to further specialize in certain topics.

Jorinde van de Vis wint de For Women in Science Rising Talent-prijs voor vrouwen in de wetenschap, voor haar proefschrift in de kosmologie en deeltjesfysica.

Hoogleraar Internationaal Belastingrecht Tanja Bender heeft een vermelding gekregen in het boek Recognising 100 Years of Women in Tax.

As per January 1st, Niek Strohmaier is part of Kifid’s arbitration committee.

Sinds 2015 roepen de Verenigde Naties 11 februari uit tot International Day of Women and Girls in Science. De Universiteit Leiden organiseerde een publieksevenement met lezingen en discussies voor ruim honderd geïnteresseerden. Tussen een lezing over de bouwstenen van leven en een talkshow over de impact…

Onze promovenda Maral Darouei heeft in samenwerking met haar dagelijkse begeleider Helen Pluut een artikel gepubliceerd in het tijdschrift Career Development International (5-year IF = 2.704). Het paper is getiteld “The paradox of being on the glass cliff: Why do women accept risky leadership positions”.…

Chinese law schools doen het internationaal zeer goed en kennis van het Chinese recht wordt voor Nederlandse studenten en stafleden steeds relevanter. In de internationaliseringsambities neemt de samenwerking met China dan ook een prominente plaats in. Dit collegejaar doen vijf wetenschappers van de…

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Een wereld zonder ziekte: toekomst of illusie? In ieder geval het nastreven waard, vinden ze bij Janssen, dat de mogelijkheden voor zo’n wereld daarom onderzoekt. Studenten van het Leiden Leadership Programme brachten voor het bedrijf enkele dilemma’s in kaart die daarbij een rol kunnen spelen.

Promotores: J. Jonkers, K.E. de Visser

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Heart failure is a major health care problem with high mortality.

Promotores:Th.J.C. van Berkel, M. van Eck

Promotie

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.

Promotor: S.M. Verduyn Lunel

Congres/symposium

Promotie

Cardiovascular disease is the leading cause of death worldwide.

Promotie

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.

Lezing

Announcement of a new publication by Janneke Verheijen, lecturer at the Institute of Cultural Anthropology and Development Sociology.

Dr. Nadine Akkerman, werkzaam aan het Leiden University Centre for the Arts in Society (LUCAS), is van 27 mei tot en met 4 juli gastdocent bij de Universiteit van Birmingham. Ze zal onder andere meedoen aan een groot publiekelijk debat en ze is de keynote spreker tijdens het internationale colloquium…

Het essay Humanistische filosofie (1990) behandelt de relatie tussen filosofie en de levensbeschouwing van het humanisme.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Control of infectious diseases poses continuous challenges for human health.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotie

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt