The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

The radio sky harbours both galactic and extragalactic sources of arcminute- to degree-scale emission of various physical origins. To discover extragalactic diffuse emission in the Cosmic Web beyond galaxy clusters, one must image low–surface brightness structures amidst a sea of brighter compact fore-…

Studievoorlichting, Online Experience

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

How do nanoparticles bioaccumulate and biodistribute in organisms?

Promotor: M.A.G.J. Orrit

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

We present an extensive study of methods for exactly solving stochastic constraint (optimisation) problems (SCPs) in network analysis. These problems are prevalent in science, governance and industry.

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

Dit artikel onderzoekt de oorzaken en onderzoekt hoe verschillende publieke percepties van de rechtsstaat bijdragen aan deze trend.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

LIACS is a partner in the EU Erasmus+ Curriculum Development for the Asian education system. The knowledge available in the field of Data Science and Artificial Intelligence education will be shared and adapted for the Asian market.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

Een van de manieren om een andere cultuur beter te begrijpen is door te onderzoeken wat mensen ervaren bij het lezen van een tekst. Of bij het zien van een beeld. Leidse experts hebben veel kennis op dit gebied, bijvoorbeeld over cultuur in het oude Japan.

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Promotor: Prof.dr. J.P. Abrahams

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Op 1 april 2020 verdedigde Marc Broekema zijn proefschrift 'Cognitive Bias in the Judgment of Business Valuations and Valuators'. Het promotieonderzoek is begeleid door promotor prof. dr. J.I. van der Rest.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Promotor: Prof.dr. P.C. van Welzen

In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

De masterspecialisatie Philosophical Perspectives on Politics and the Economy van de Universiteit Leiden was voorheen bekend onder de naam Philosophy, Politics and Economics.

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

Prof.dr. Niels Schiller is experimenteel taalwetenschapper. Hij houdt zich bezig met verwerkingsprocessen van taal in de hersenen en werkt nu aan een videobril voor doven en slechthorenden.

Het zinnetje ‘ijs en weder dienende’ is een goed voorbeeld van de zogenoemde deelwoordconstructie en misschien wel een van de meest ondoorgrondelijke van het Nederlands. Want wat (of wie) dient nu wie (of wat)? De betekenis is eigenlijk ‘als het ijs en weer meezitten’. De oratie van Gijsbert Rutten,…

Het ligt misschien niet echt voor de hand, maar het Nederlands is na het Engels waarschijnlijk de best onderzochte taal ter wereld. Al die grammaticale kennis wordt nu gebundeld in een website: TaalPortaal.

Sinoloog en gastconservator van het Taalmuseum Jeroen Wiedenhof vertelt Sleutelstad FM over Vol van karakter, een expositie die aan de hand van unieke én alledaagse voorwerpen laat zien hoe Chinezen met taal omgaan.

This thesis is about augmented reality (AR). AR is commonly considered a technology that integrates virtual images into a user’s view of the real world.

We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.

Promotor: J. Zaanen, Co-Promotor: V. Juricic

Promotor: Prof.dr. G.P. van Wezel