This Thesis describes a strategy to synthesize 1,2-cis-oligosaccharides modulated by additives, such as dimethylformamide (DMF), triphenylphosphine oxide (Ph3P=O) and N-methyl(phenyl)formamide (MPF), using building blocks that carry solely benzyl type protecting groups and are therefore of uniform r…

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Control of infectious diseases poses continuous challenges for human health.

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Promotor: Prof.dr. G.R. de Snoo

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

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Promotor: H.V.J. Linnartz

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Promotor: A. Kros

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.

Promotores: W. Jiskoot, F. Ossendorp

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

Het schema hieronder geeft het curriculum weer van het eenjarige fulltime programma van de master Health, Ageing and Society in collegejaar 2024-2025.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted…

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Big Science, commonly defined as conventional science made big in three dimensions, namely organizations, machines, and politics, brings a plethora of different stakeholders together, often for a long period of time. This includes policymakers, scientists, (scientific) managers as well as local “host”…

Bij eLaw verzorgen we een aantal vakken voor de master Jeugdrecht en voor de master International Children's Rights (Advanced LL.M.)

Lezing

The main aim of this project is to reveal and unravel the invisible histories of the UN, transcending the dominant Western perspective to recover the historical agency of Global South actors. The research will investigate how the UN has both facilitated and limited their role in shaping global order…

De YAL laat zich horen over beleidskwesties.

Een diversere groep studenten kun je je bijna niet voorstellen. India, Duitsland, Pakistan, Nederland, Israël, Rusland, Italië en Mongolië, allemaal voorbeelden van landen die dit voorjaar vertegenwoordigd zijn in de pilot van het International Leiden Leadership Programme.

Congres/symposium

Promotie

To deliver a Virtual Sensor tool optimised to exploit the synergy between Sentinels 2 and 3 to allow the consistent retrieval of land surface parameters (Albedo, LAI, and LST); To extend the existing capabilities of land EO data assimilation tools to add capacity to handle data in the thermal domain…

Using the principles of Industrial Ecology in Environmental Policy making in two cases: transition to a hydrogen economy and chlorinated compounds.

How to ensure the environmental and economic benefits of circularity transition at macro-scale?

The research presented in this thesis concerns one of the most important questions in software engineering of our time: how can we make sure that software is free from memory safety bugs?

In de landelijke Onderzoekschool Mediëvistiek werken onderzoekers op het gebied van de Middeleeuwen van zes Nederlandse universiteiten samen. De school verzorgt (in samenwerking met de lokale graduate schools van de universiteiten) de opleiding tot mediëvistisch onderzoeker en biedt ook opleidingsactiviteiten…

Hoe en in welke mate kunnen groepen clinici en biomedici kennis uit klinische vakken en kennis uit de basisvakken expliciet maken en aan elkaar relateren?

De conservatoren en de restaurator schrijven regelmatig blog-posts over fysieke objecten uit de Bijzondere Collecties.

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Promotor: A.P. IJzerman

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

During the course of drug discovery translational steps are made.