Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Promotor: Prof.dr. J.W.M. Frenken

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

An important part of the SCS specialisation is the internship period. Students will get the opportunity to get to know the field and to apply what they have learned during the courses.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Over the last decades, aviation safety has improved strongly. As a downside, airline pilots do not have as many opportunities to develop through experience the competencies that they need in critical situations.

The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

Development of GHG calculator for bio-electricity and heat.

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Studievoorlichting

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

The project Multimedia Research and Documentation of African Oral Genres: Connecting Diasporas and Local Audiences (Director: D.Merolla) focuses on multimedia as technology that allows scholars to share documentation and scientific knowledge with the cultural owners of the collected oral genres.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.

Lezing

Geesteswetenschappen, Centre for the Arts in Society

Cursus, Training

Negentien studenten die excellente resultaten behaalden tijdens de minor Intelligence Studies ontvingen dit jaar de Kluitersprijs.

De oorlog tussen Rusland en Oekraïne speelt niet alleen fysiek maar ook digitaal. Van Den Berg, Hoogleraar Cybersecurity Governance aan de FGGA, vertelde erover bij meerdere nieuwsoutlets.

Als chemicus, voormalig wetenschapsjournalist en nu als docent wetenschapscommunicatie raakte ik geïntrigeerd door de brand bij Chem-Pack in Moerdijk. Feiten werden niet of slechts sporadisch gecommuniceerd. Allerlei indianenverhalen bereikten wel het publiek, mede door het optreden van minister Opstelten…

Op donderdag 29 oktober organiseert Kennis Maken Den Haag de derde editie van Den Haag Draait Door. In deze online talkshow gaan experts en beleidsmakers in gesprek over problemen die spelen in de stad Den Haag. Ook bij deze editie zijn studenten, onderzoekers en inwoners uit de regio van harte welk…

Het Algemeen Dagblad besteedt aandacht aan een college van hoogleraar Informatica en Recht Jaap van den Herik voor de Universiteit van Nederland, waarin hij betoogt dat computers in de toekomst prima zouden kunnen rechtspreken.

KPN heeft op 12 maart de zesde editie van de European Cyber Security Perspectives gepubliceerd. Sergei Boeke, onderzoeker aan het Insitute of Security and Global Affairs, heeft hierin een artikel geschreven over Cyber Warfare.

Bibi van den Berg, Hoogleraar Cybersecurity Governance, verscheen afgelopen week verschillende keren in het nieuws over de internationale ransomeware-aanval en de impact daarvan.

Bibi van den Berg, hoogleraar Cybersecurity Governance aan het institute of Security and Global Affairs, praat over de verantwoordelijkheden na incidenten omtrent cybersecurity.

De voorspelling van Jaap van den Herik, directeur van het Leiden Centre of Data Science, is uitgekomen: Google-computer AlpaGo heeft de wereldkampioen Go verslagen met 4-1. In interviews met de Volkskrant en BNR Nieuwsradio vertelt Van den Herik over het toernooi én over de volgende uitdaging: het spel…

Caspar van den Berg praat bij Radio 1 over zijn zorgen om de kloof tussen stad en de landelijke randgemeenten.