The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

Promotor: Prof.dr. M. Ubbink

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: Prof.dr. G.J. Kroes

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

Creating a framework to assess the sustainability of fish farms which will set sustainability standards and give consumers information about the the sustainability and safety of their seafood.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

The aim of this project was to estimate emissions from lead products-in-use for the past, the present and the future and assess the development of toxicological risks associated with these products.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Possible improvements for the assessment of abiotic depletion in LCA.

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

De in de introductie geschetste ontwikkelingen leiden ertoe dat huishoudens meer verantwoordelijk gaan dragen voor sociale risico’s, meer zelf moeten plannen, over een langere periode en onder meer onzekerheid.Dit geldt niet alleen in Nederland, maar ook in andere westerse landen. Dit leidt tot de onderstaande…

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Alumni-activiteit, Carrière

Alumni-activiteit

Jaarlijks organiseert het Alumnibureau van de Universiteit Leiden een aantal masterclasses. Deze masterclasses zijn exclusief toegankelijk voor Leidse alumni.

Alumni-activiteit, Activiteit Chemisch Dispuut Leiden

Marliese Vollebregt (BA International Studies, MA International Relations) werkt bij JINC, een Nederlandse non-profitorganisatie die streeft naar een maatschappij waarin de achtergrond van een kind niet zijn of haar toekomst bepaalt. Vóórdat ze de arbeidsmarkt opging was ze een aantal maanden ski-instructeur…

Het Natuurwetenschappelijk Gezelschap Leiden organiseert lezingen en excursies voor alumni en (oud-)medewerkers van de Faculteit Wiskunde en Natuurwetenschappen en het LUMC én geïnteresseerden uit de regio Leiden.

Alumni kunnen op verschillende manieren deelnemen aan (vervolg)onderwijs en cursussen die de Universiteit Leiden aanbiedt. Ook organiseert het Alumnibureau een aantal keer per jaar masterclasses rondom een actueel onderwerp, speciaal voor Leidse alumni.

De faculteiten van de Universiteit Leiden onderhouden op verschillende manieren contact met alumni van hun faculteit.

Het Alumnibureau onderhoudt het contact met alumni van de Universiteit Leiden en houdt zich bezig met de organisatie van universitaire alumni-activiteiten evenals het faciliteren en ondersteunen van de faculteiten en de studie- en alumniverenigingen.

Meer dan dertig onderzoeksprojecten ontvangen een subsidie van het Leids Universiteits Fonds (LUF). De wetenschappers krijgen ieder een bedrag tussen de 5.000 en 25.000 euro om hun onderzoek uit te voeren.

Alumni-activiteit, Arbeidsmarktvoorbereiding

uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.

Since its beginnings, Leiden University has been home to scholars with a broad and diverse expertise in the histories, languages, literatures and material cultures relevant to the study of Jews and Judaism from antiquity to modern times.

Description of Atlas of the surfacewater concentrations of pesticides in the Netherlands, a pilotstudy.

Examining the sustainability aspects of biotechnology, especially those related to the production of ethanol from biomass.

1) Assess the trends in supply and production status of these critical minerals and mineral products worldwide and Europe’s dependence including on intermediate products such as permanent magnets, RE based super alloys, batteries, polishing compounds, phosphors, catalysts etc. 2) Trace the entire value…

Rond 26 november worden op ruim veertig locaties wereldwijd Cleveringabijeenkomsten georganiseerd voor Leidse alumni. Zo ook in Tokio, waar hoogleraar Japanstudies Ivo Smits zijn Cleveringalezing hield voor een volle zaal.

Alumni-activiteit

Alumni-activiteit

Loopbaan en solliciteren