Promotor: J. Kuiper

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

Op 2 oktober 2023 is de eerste editie van de LUMC Women Collegetour georganiseerd. In deze eerste Collegetour sessie, in Bioscoop Trianon in Leiden, is gesproken met transplantatiechirurge Dorottya de Vries. De sessie is gehouden voor tweedejaars studenten Geneeskunde. Onder begeleiding van interviewer…

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Hoeveel sterren zijn er in het heelal? En hoe komt het dat astronauten kunnen 'zweven' in de ruimte? Op de Universiteit Leiden krijg je op zaterdag 9 februari antwoord op heel veel vragen over sterrenkunde.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Gaat de toenemende deelname van vrouwen aan verkiezingen in ruraal India het bestuur verbeteren?

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Leiden Law Park zal de binnenstadscampus worden waarin wetenschap, bedrijfsleven, overheid en burgers samenkomen om kennis te ontwikkelen en te delen op het snijvlak van recht, ethiek en technologie.

In het Leiden Bio Science Park (LBSP) werkt de Universiteit Leiden samen met het bedrijfsleven, het LUMC en de Gemeente Leiden.

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

Promotor: Prof.dr. J. Kuiper

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Het Leiden Bio Science Park (LBSP) is het grootste innovation district van Nederland op het gebied van Life Sciences & Health. De clustering van hoogwaardig onderwijs, onderzoek, zorg en bedrijfsleven trekt studenten, wetenschappers en ondernemers vanuit de hele wereld naar kennisstad Leiden. Het LBSP…

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

This thesis attempts to interrogate post-1991-2015 political development in Ethiopia, focusing on the political discourses espoused by the government and opposition, using the discourse analysis method and securitization theory.

Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

What is the population size and social structure in time and space? What is the lion diet and food preference in time and space? What is the home range (MCP and Kernel) and movement in time and space? What are human – lion conflict and responses of lions to traditional herding in time and space? What…

Psycholoog Bernadet Klaassens heeft een groot fMRI-onderzoek opgezet naar het effect van medicijnen op hersennetwerken bij veroudering en de ziekte van Alzheimer. Het leverde een unieke dataset op en zicht op een nieuwe methode om medicijnen te ontwikkelen voor patiënten met Alzheimer.

Dit artikel onderzoekt de inspanningen van gezaghebbende Turkse maatschappelijke actoren om de stem van moslimvrouwen in Nederland te versterken.

Promotor: E.F. Smets, Co-promotor: T.R. van Andel

How to contribute to a quantum leap of eco-industrial symbiosis in China?

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The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

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Promotores: H.A. Udo De Haes, P.M. Brakefield

In dit artikel bestuderen de auteurs hoe individuele variabelen en variabelen op landelijk niveau op elkaar inwerken bij het beïnvloeden van politieke genderattitudes in Europa.

Women In International Security (WIIS) is a global organisation dedicated to advancing the leadership and professional development of women in the field of international peace and security. As part of her research on women, peace and security, Dr. Vanessa Newby at the Institute for Security and Global…

De eerste paal is 6 november de grond ingegaan voor een nieuw gebouw voor Eurofins in het Oegstgeester deel van het Bio Science Park, dat op grond van de Universiteit Leiden in erfpacht wordt uitgegeven. Hiermee wil het bedrijf ruimte creëren voor groei én een efficiëntieslag slaan.

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

Some examples of research questions include: What framework of circular strategies should local practitioners use? How should practitioners organize their monitoring of the circular economy activities in the region of interest? What are the main products that have the most circular potential in the…

Deelproject van

What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…

In de laatste nieuwsbrief van het Leiden Bio Science Park staat o.a. informatie over een nieuw Europees onderzoeksproject, het 25e Lab Career Event en het kennisfestival 2009!